Example: Consider the integral
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We try the substitution

Thus we get
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which does not look any better than the original problem, perhaps even worse. So this particular substitution did not help and other substitutions are not apparent.
Example: Consider the integral
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We try this substitution:
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We get
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and the substitution did not help, creating x turned out to be too complicated. No method covered in Math Tutor would help with this new integral.
Example: Consider the integral
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Here we have x in the denominator, which just begs for the
substitution

Although this integral looks somewhat better than the original one, we still do not know how to evaluate it - the sine function still spoils it and there is no way to get rid of it via substitution.
Remark: The difference between success and failure can be very small. On the page with examples of successful substitutions we had the integral
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which we easily solved by denoting the whole denominator by y. Now we make a little change:

The expression next to dx differs by one from the numerator and this missing one can not be fixed. The only hope would be to write
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and then substitute for x by solving the basic substitution equality; however, this we cannot do (we do not know how to solve polynomials of the third degree using a nice formula). Thus for this integral substitution does not help, just because a one instead of a two at the wrong place.